6 edition of Combinatorial chemistry and technology found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Stanislav Miertus, Giorgio Fassina.|
|Contributions||Miertus, Stanislav., Fassina, Giorgio, 1960-|
|LC Classifications||RS419 .C59 1999|
|The Physical Object|
|Pagination||xii, 435 p. :|
|Number of Pages||435|
|LC Control Number||99015461|
Combinatorial Chemistry: Synthesis and Application The new time-saving revolution in drug discovery. Medical books Combinatorial Chemistry. br> Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working. Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both the substrate (estrone or estradiol) and the cofactor (NAD(P)H) binding sites, we used parallel solid-phase synthesis to prepare three.
The first single-author book on this growing field, it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimization of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for students and academic and industrial researchers in Price: $ Non-combinatorial chemistry is a powerful technology for the synthesis of large numbers of compounds, with complete control over the properties of those compounds.
The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Combinatorial Chemistry represents a mixture of chemistry and biology. It involves the use of computers and technology to create a massive array of different, but structurally related/similar, molecules in order to investigate a specific molecule and its derivatives.
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Combinatorial Chemistry. Combinatorial chemistry is a technique originally developed for the synthesis of large chemical libraries for high-throughput screening against such targets,80 which coupled to the development of robotic systems and tools, such as solid-phase synthesis and new immobilization strategies involving novel resins, reagents, and linkers, has permitted high-throughput.
The first single-author book on this growing field, it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimization of biologically active molecules.
This concise and comprehensive overview of combinatorial techniques is an essential text for students and academic and industrial researchers in 5/5(1).
Combinatorial chemistry and natural products were often seen as juxtaposed techniques to access meaningful drug candidates. In late s and early s the hype on combinatorial chemistry and large pool libraries was so great that many people believed that meaningful chemical diversity would predominantly be gained through combinatorial methods.
Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development.
It covers all the organic chemistry technology available at the time of writing and is the only book of its kind concerning the Author: Stephen R.
Wilson. 2. •Combinatorial Chemistry is a new method developed by academics and researchers to Combinatorial chemistry and technology book the time and cost of producing effective, marketable and competitive new drugs. • Scientists use Combinatorial Chemistry to create large numbers of molecules that can be detected efficiently.
•This technique has captured the attention of many. ISBN: OCLC Number: Description: xv, pages: illustrations ; 23 cm: Contents: Ch. Combinatorial chemistry and combinatorial technologies: principles and applications / Giorgio Fassina and Stanislav Miertus --Ch.
atorial chemistry: from split-mix to discrete / Arpad Furka --Ch. eptide libraries / Daniela Palomba and Giorgio Fassina. Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research.
Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new.
Having studied Chemistry in Münster and Konstanz, he worked as a postdoctoral fellow with Sir A. Battersby in Cambridge (UK). Inhe joined Roche in Basel (Switzerland) where he was head of nucleotide and peptide chemistry and later was named head of combinatorial chemistry, a technique which he had introduced at Roche.
In biotechnology, combinatorial biology is the creation of a large number of compounds (usually proteins or peptides) through technologies such as phage r to combinatorial chemistry, compounds are produced by biosynthesis rather than organic process was developed independently by Richard A.
Houghten and H. Mario Geysen in the s. Solution phase combinatorial chemistry It is the modified reaction to accommodate a solid support. Solution phase combinatorial chemistry often lead to a formation of Mixture of product. May helpful for development of Amazing-MixtureProblems: # difficulty of removing unwanted material # purification at each step is necessary # other.
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, particularly in pharmaceuticals. This informative text explains the origins of combinatorial chemistry and provides a context for the many diverse library methods.
It explains why some techniques are generally applicable while others are for specialists only. The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today.
Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of. References Text book of Medicinal Chemistry Volume-IIina Pg no: A Text book of Synthetic and Medicinal Chemistry Rao Pg no: Combinatorial chemistry: A Review Drug Invention Today VolIssueJanuary Pg no: Combinatorial chemistry and its application – a review AK Mishra, A Gupta, AK.
Bentham Science - STM publisher of online and print journals, and related print/online book series. Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences.
Combinatorial Chemistry in Drug Design Combinatorial chemistry is somewhat hard to define. Essentially, it is a collection of techniques which allow for the synthesis of multiple compounds at the same time.
These techniques are now largely automated, but do not necessarily have to be. Get this from a library. Combinatorial materials synthesis. [Xiao-Dong Xiang; Ichiro Takeuchi;] -- This text reveals the gears behind combinatorial materials chemistry and thin-film technology, putting forth the prime techniques involved in synthesis and property determination for experimentation.
Research Data Reporting in Chemistry. Preparing Your Data for Publication. Data Management. The Future of Data Sharing. Chemical Structures in the Google Era. Human vs Machine Interpretation. Traditions for Drawing Chemical Structures. Combinatorial Chemistry and Technologies: Methods and Applications, Second Edition - CRC Press Book Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all.
About this book With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures.
These compound libraries are a cost-effective resource for the pharmaceutical industry. Electrochemical screening of tungsten trioxide - nickel oxide thin film combinatorial library at low nickel concentrations Jun-Seob Lee, Cezarina Cela Mardare, Andrei Ionut Mardare, and Achim Walter Hassel.Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery.
This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.This book comprehensively describes the development and practice of DNA-encoded library synthesis technology.
Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening.